Author's response to reviews Title: Attenuated expression of histamine receptor H4 in colorectal cancers: a potential correlation with histamine-mediated tumor growth Authors:
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Author's response to reviews: We have seeked two fluent English speaking colleagues to correct the language in our manuscript. The revisions have been marked in the main document. And particular attention has been paid to the abstract. Thanks for your advice.
منابع مشابه
Deletion and Down-Regulation of HRH4 Gene in Gastric Carcinomas: A Potential Correlation with Tumor Progression
BACKGROUND Histamine is an established growth factor for gastrointestinal malignancies. The effect of histamine is largely determined locally by the histamine receptor expression pattern. Histamine receptor H4 (HRH4), the newest member of the histamine receptor family, is positively expressed on the epithelium of the gastrointestinal tract, and its function remains to be elucidated. Previously,...
متن کاملThe role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer.
PURPOSE Activity of histidine decarboxylase, the key enzyme in the synthesis of histamine, has been shown to be increased in several types of human tumors. We attempted to establish whether the possible involvement of histidine decarboxylase and histamine in colorectal carcinogenesis might be mediated by the activation of the cyclooxygenase-2 (COX-2) pathway. EXPERIMENTAL DESIGN Expression/ac...
متن کاملAuthor's response to reviews Title: Elevated IGFIR expression regulating VEGF and VEGF-C predicts lymph node metastasis in human colorectal cancer Authors:
“...Lymphangiogenic factors, such as VEGF-C and VEGF-D, have been show to stimulate tumor lymphangiogenesis and metastasis to regional lymph nodes by interacting with their receptor VEGF receptor 3 (VEGFR-3). High levels of VEGF-C and VEGF-D can promote tumor growth and lymph node metastasis in human colorectal cancer. Moreover, strong expression of VEGF-C and VEGF-D was significantly linked to...
متن کاملINCREASED HISTAMINE Hi RECEPTOR BLOCKADE BY CHLORPHENIRAMINE IN TRACHEAL CHAINS OF ASTHMATIC GUINEA PIGS
Receptor affinity and drug delivery to the receptor sites could be determinant factors for the increased bronchial responsiveness seen in asthma. Competitive antagonism blockade which is measured as dose ratio-l (DR-I) depends only on these two factors. Therefore, in this study we have examined histamine HI blockade by chlorpheniramine on isolated tracheal chains of asthmatic compared to co...
متن کاملHistamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells.
The diverse physiological functions of histamine are mediated through distinct histamine receptors. Mast cells are major producers of histamine, yet effects of histamine on mast cells are currently unclear. The present study shows that histamine induces chemotaxis of mouse mast cells, without affecting mast cell degranulation. Mast cell chemotaxis toward histamine could be blocked by the dual H...
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تاریخ انتشار 2011